Take your vitamin C. Make your skin beautifully happy.
Vitamin C is an essential factor in the skin health and appearance. It protects skin against stress and damage. It also has become a part of everyday personal skin care as a component in many cosmetic products.
Vitamin C maintains a healthy, young looking complexion through its effect on collagen, a protein supporting skin and skin blood vessels. It also helps the skin to heal, since collagen is necessary in the wound healing.
Vitamin C defends skin against damages by oxidative stress. As the most important antioxidant in the skin, it neutralizes free radicals, the harmful products of oxidative stress. The skin, as a barrier between the body and environment, is permanently exposed to environmental stress that generates ROS (reactive oxygen species). Certain skin conditions, such as acne or rosacea, generate free radicals subjecting skin to oxidative stress. (Read more on rosacea and acne as oxidative stress skin conditions in the inserts below). Oxidative stress created by free radicals results in oxidative damage to the skin and can induce a number of undesirable skin responses, including inflammation.
Skin has a well-organized system to counter oxidative stress, and vitamin C is in the first line of that system. For example, even after minimal exposure to the UV light, a free radical generating factor, the amount of vitamin C in the skin can diminish by 30%. In ozone-polluted air of big city, the vitamin C loss in response to the ozone stress can be as great as 55% percent. This means that vitamin C interacts instantly and directly with the products of oxidative stress and by neutralizing them protects cells against oxidative damage. The loss of vitamin C can be compensated by supplementation of vitamin C. When taken daily, as a complement to the everyday personal skin care, the supplement increases amount of vitamin C available in the skin. A good supply of vitamin C helps the skin to counter the oxidative damage by environmental stress or skin conditions, such as rosacea or acne. This makes the skin less sensitive to sunburns, alleviates skin redness and keeps down the blood flow in facial small blood vessels.
In summary, vitamin C supports all types of skin and helps to stay healthy and beautiful at every stage of life or skin condition:
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Vitamin C provides a first line of defense against environmental challenges, especially for sensitive, overreacting types of skin, like in rosacea or acne;
Skin prefers a supplement of vitamin C.
Vitamin C, as ascorbic acid or its derivatives, is used in cosmetic products for variety of applications, among others, in reduction of the erythema of rosacea skin. Cosmetic products, delivered through the skin surface, are limited by the ability of a vitamin C component to enter the skin through the skin barrier and be included into the skin cells.
Unlike most cosmetic applications, vitamin C delivered as a supplement enters the body, is transformed to an active form and included into skin cells’ many functions. For rosacea or acne skin it means better antioxidant protection at the sites of the oxidative damage brought by these skin conditions. Similarly, systemic (oral) delivery would be preferred in how vitamin C supports skin health and appearance through its effect on skin collagen and wound healing.
We suggest our Vitamin C-Ginger-Calcium Antioxidant Blend tablets as an antioxidant support for rosacea or acne skin. It will help to increase the antioxidant abilities of the body to counter oxidative damage to the skin by rosacea or acne. Based on our own data as well as opinion of other specialists, antioxidant support of everyday skin care helps attain a healthier, beautiful complexion for skin with rosacea or acne-like symptoms.
Rosacea is an oxidative stress condition.
Although the pathogenesis of rosacea remains unknown, development of chronic inflammation is undoubtedly a central process in this skin condition. Some specialists even argue that all symptoms of rosacea are manifestations of inflammatory processes, a condition known as neutrophilic dermatosis. Recent evidence indicates that the rosacea inflammation is associated with the generation of ROS and other inflammation mediators released by inflammatory cells such as neutrophils. Rosacea patients have increased levels of ROS activity while at the same time their ascorbic acid level (the active form of vitamin C and a major antioxidant in the skin) is decreased.
The neutrophil-genetated ROS, together with other free radicals may contribute to the clinical manifestations of rosacea through oxidative tissue damage. For that reason, rosacea can be characterized as oxidative stress condition and as such helped by systemic use of supplemental vitamin C, preferably in the form of ascorbic acid. Ascorbic acid, an active form of vitamin C, is known to prevent the redness induced by oxidative stress in the skin treated with UV light.
Acne inflammation is mediated in part by reactive oxygen species.
Clinical data indicate that the reactive oxygen species generated by neutrophils have a role in acne inflammation. In people with acne, the neutrophils’ ability to produce reactive oxygen species, ROS, was significantly increased and their oxidative stress level was higher then normal. This indicates that the acne inflammation is mediated in part by hydrogen peroxide, a reactive oxygen product of neutrophils. The neutrophil-generated hydrogen peroxide is thought to interact with skin lipids and form oxidized lipid products. The oxidized lipids overwhelm the skin's antioxidant barrier and generate processes responsible for inflammation in acne. Subsequent bacterial colonization of follicles and the skin surface is a secondary event that aggravates the ROS induced damage.
Clinically effective products recommended for acne, e.g. metronidazole or anti-inflammatory antibiotics, often are advertised as proven to significantly inhibit ROS production. They are said to work by decreasing neutrophil-generated ROS at the sites of inflammation, thus protecting skin against oxidative injury. However, the accompanying side effects are often detrimental and discouraging.
Vitamin C, with its ability to neutralize ROS, supports skin by helping to diminish the oxidative damage and resulting inflammation. When added to the everyday skin care it can improve health and appearance of acne skin or any type of skin with inflammation.
Read more about vitamin C:
www.nlm.nih.gov/medlineplus/vitamins, www.nih.gov/news, www.vitamincfoundation.org
A PERSONAL NOTE FROM DR. PIOTR CHOMCZYNSKI
Dear Customer,
We are pleased to provide you with a patent-pending pill containing a Vitamin C - Calcium - Ginger Antioxidant Blend. This is our most recent entry in improvements of skin appearance in people affected by rosacea or acne.
There has been speculation that chemicals called free radicals, especially reactive oxygen species, play a role in triggering inflammatory skin conditions appearing in acne and rosacea. For this reason, certain cosmetics include vitamin C in their list of ingredients. However, topical delivery of vitamin C seems to be not highly effective. Our research indicates that oral use of Vitamin C - Calcium - Ginger blend combined with the topical use of Noredol® Skin Care Gel improves conditions of skin affected by rosacea and acne. Oral Vitamin C is an important antioxidant that counteracts reactive oxygen species damage in human tissues. Vitamin C may also improve appearance by promoting skin collagen synthesis.
The Vitamin C - Calcium – Ginger pills contain about 450 mg of vitamin C and should be taken two times a day. This is higher than the recommended daily allowance of 60 mg per day of vitamin C. But numerous studies using very high amounts of vitamin C, up to seven grams a day, showed no side effects with these very high doses. (These other studies examined vitamin C as a treatment for things like cancer, inflammation and the
common cold.) To be safe, if you are pregnant or nursing, taking medication, have bleeding or other medical problems, consult a physician before taking this product.
In conjunction with taking this pill orally, apply Noredol® Skin Care Gel two-three times a day to your skin. Take one pill in the morning or in the evening, with or without food. Please take additional pill if you experience factors that trigger your skin condition to become worse, such as high intensity exercise, exposure to bright sun light, extreme temperatures or foods that trigger rosacea (for example coffee or tea). We recommend taking the pill before the exposure.
We expect that addition of the Vitamin C - Calcium - Ginger antioxidant blend into your daily routine, along with your continued use of Noredol® Skin Care Gel, will result in further improvement of your skin appearance.
A recent review indicates that many health claims associated with vitamin C are not confirmed in studies of large human populations. The one effect which seems to be confirmed is that vitamin C helps to handle physical stress. Similar to this finding, our study indicates that the vitamin C-Calcium-Ginger antioxidant blend can improve the appearance of skin affected by stress due to environmental factors such as extreme weather or sun, and of skin stressed by conditions such as rosacea. In our studies, about 40% of people noticed skin improvement after taking the Vitamin C antioxidant blend. Take advantage of our free offer and judge for yourself. For a limited period of time we provide a free bottle of this vitamin blend. Please send us an email with your comments and results.
Sincerely,
Piotr Chomczynski, PhD |
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