Noredol<sup>®</sup> News No.10, 2007
E-Publication of Cinna Health Products, a divison of Molecular Research Center, Inc.
Skin care news, science news, answers to general questions and tips for your good health, and what people are saying about
Noredol® Skin Care Gel, a new generation of cosmetics.
divider

Noredol® News

    Previous Issue
    Archives

Noredol® Home
    How to Use
    About Noredol
    FAQ
    Testimonials
    About Cinna
    Order Page

Contact Us

 
Another happy Noredol<sup>®</sup> user

Noredol® Skin Care Gel is a cosmetic and can be used to cosmetically improve appearance of your skin.  Noredol® Skin Care Gel is designed as a cosmetic to be applied on sensitive skin including skin affected by rosacea.  It does not cure, alleviate or prevent any skin disease.


NOREDOL® NEWS

Cinna Health Products is pleased to offer a new product:

Vitamin C - Ginger - Calcium  Antioxidant  Blend.

Skin needs a supplement of vitamin C.

The tablets with Vitamin C-Ginger-Calcium increase the antioxidant defenses of the body and help counter damages to the skin by acne or rosacea. The tablets also support skin health and appearance through the effect on skin collagen and skin healing. 

Based on our data, the Vitamin C-Ginger-Calcium Antioxidant Blend helps maintain a healthy, beautiful complexion in skin with rosacea or acne.

To inquire about Cinna’s Vitamin C-Ginger-Calcium Antioxidant Blend contact us:
support@noredol.com
1-866-NOREDOL



Favorite New Quote:

“I started using the Noredol one month ago and I am so pleased with the results! My Dermatologist told me that the next step was Laser for the redness of Rosacea. I was so unhappy with my red face, and then I found the Cinna Health Products and NOREDOL. Now my face is clear of the redness.  Thank you.”

                                                                                           Irma D.,   Dozier, Alabama





BOOKS



Vitamin C: Everything You Need to Know
by Jennifer Hay,
Peoples Medical Society Pub., 1998
ISBN: 9781882606368


Users Guide to Vitamin C
by Hyla Cass,
Basic Health Pubns, 2002
ISBN: 1591200210


The Antioxidant Miracle: Put Lipoic Acid, Pycnogenol, and Vitamins E and C to Work for You
by Lester Packer and Carol Colman,
John Wiley & Sons, 1999
ISBN: 978-0471353119


Breaking Out: A Woman's Guide to Coping with Acne at Any Age
(Paperback)

by Lydia Preston and Tina Alster,
Simon & Schuster, 2004
ISBN: 9780743236232


Joy-Full Holistic Remedies
by Georgie Holbrook,
144 pp.
Joy-Full Publishing Company, 1999
ISBN: 047084518X



(Cinna Health Products does not endorse books or authors listed in the BOOKS.)


FACE TIME

       Take your vitamin C.                                                             Make your skin beautifully happy.         

Vitamin C is an essential factor in the skin health and appearance. It protects skin against stress and damage. It also has become a part of everyday personal skin care as a component in many cosmetic products. 

Vitamin C maintains a healthy, young looking complexion through its effect on collagen, a protein supporting skin and skin blood vessels. It also helps the skin to heal, since collagen is necessary in the wound healing.

Vitamin C defends skin against damages by oxidative stress. As the most important antioxidant in the skin, it neutralizes free radicals, the harmful products of oxidative stress. The skin, as a barrier between the body and environment, is permanently exposed to environmental stress that generates ROS (reactive oxygen species). Certain skin conditions, such as acne or rosacea, generate free radicals subjecting skin to oxidative stress. (Read more on rosacea and acne as oxidative stress skin conditions in the inserts below). Oxidative stress created by free radicals results in oxidative damage to the skin and can induce a number of undesirable skin responses, including inflammation.

Skin has a well-organized system to counter oxidative stress, and vitamin C is in the first line of that system. For example, even after minimal exposure to the UV light, a free radical generating factor, the amount of vitamin C in the skin can diminish by 30 %. In ozone-polluted air of big city, the vitamin C loss in response to the ozone stress can be as great as 55% percent. This means that vitamin C interacts instantly and directly with the products of oxidative stress and by neutralizing them protects cells against oxidative damage.  The loss of vitamin C can be compensated by supplementation of vitamin C.  When taken daily, as a complement to the everyday personal skin care, the supplement increases amount of vitamin C available in the skin.  A good supply of vitamin C helps the skin to counter the oxidative damage by environmental stress or skin conditions, such as rosacea or acne.  This makes the skin less sensitive to sunburns, alleviates skin redness and keeps down the blood flow in facial small blood vessels.

In summary, vitamin C supports all types of skin and helps to stay healthy and beautiful at every stage of life or skin condition:

  • Vitamin C provides a first line of defense against environmental challenges, especially for sensitive, overreacting types of skin, like in rosacea or acne;
  • As an indispensable factor in healing of the skin, vitamin C helps in advanced stages of acne or rosacea characterized by skin scaring;
  • Vitamin C supports skin and blood vessels; this is especially important for the facial skin and small facial blood vessels weakened by rosacea;
  • Vitamin C alleviates facial redness resulting from skin conditions, such as rosacea or acne or skin exposure to UV light; 
  • Vitamin C helps the skin with unbalanced free radicals formation, as in rosacea or acne. 

Skin prefers a supplement of vitamin C.

Vitamin C, as ascorbic acid or its derivatives, is used in cosmetic products for variety of applications, among others, in reduction of the erythema of rosacea skin. Cosmetic products, delivered through the skin surface, are limited by the ability of a vitamin C component to enter the skin through the skin barrier and be included into the skin cells.

Unlike most cosmetic applications, vitamin C delivered as a supplement enters the body,  is transformed to an active form and included into skin cells’ many functions.  For rosacea or acne skin it means better antioxidant protection at the sites of the oxidative damage brought by these skin conditions.  Similarly, systemic (oral) delivery would be preferred in how vitamin C supports skin health and appearance through its effect on skin collagen and wound healing.

We suggest our Vitamin C-Ginger-Calcium Antioxidant Blend tablets as an antioxidant support for rosacea or acne skin. It will help to increase the antioxidant abilities of the body to counter oxidative damage to the skin by rosacea or acne.  Based on our own data as well as opinion of other specialists, antioxidant support of everyday skin care helps attain a healthier, beautiful complexion for skin with rosacea or acne-like symptoms.



                                             Rosacea is an oxidative stress condition.

Although the pathogenesis of rosacea remains unknown, development of chronic inflammation is undoubtedly a central process in this skin condition. Some specialists even argue that all symptoms of rosacea are manifestations of inflammatory processes, a  condition known as neutrophilic dermatosis. Recent evidence indicates that the rosacea inflammation is associated with the generation of ROS and other inflammation mediators released by inflammatory cells such as neutrophils.  Rosacea patients have increased levels of ROS activity while at the same time their ascorbic acid level (the active form of vitamin C and a major antioxidant in the skin) is decreased.

The neutrophil-genetated ROS, together with other free radicals may contribute to the clinical manifestations of rosacea through oxidative tissue damage. For that reason, rosacea can be characterized as oxidative stress condition and as such helped by systemic use of supplemental vitamin C, preferably in the form of ascorbic acid. Ascorbic acid, an active form of vitamin C, is known to prevent the redness induced by oxidative stress in the skin treated with UV light.


                           Acne inflammation is mediated in part by reactive oxygen species.

Clinical data indicate that the reactive oxygen species generated by neutrophils have a role in acne inflammation. In people with acne, the neutrophils’ ability to produce reactive oxygen species, ROS, was significantly increased and their oxidative stress level was higher then normal. This indicates that the acne inflammation is mediated in part by hydrogen peroxide, a reactive oxygen product of neutrophils. The neutrophil-generated hydrogen peroxide is thought to interact with skin lipids and form oxidized lipid products. The oxidized lipids overwhelm the skin's antioxidant barrier and generate processes responsible for inflammation in acne. Subsequent bacterial colonization of follicles and the skin surface is a secondary event that aggravates the ROS induced damage.

Clinically effective products recommended for acne, e.g. metronidazole or anti-inflammatory antibiotics, often are advertised as proven to significantly inhibit ROS production. They are said to work by decreasing neutrophil-generated ROS at the sites of inflammation, thus protecting skin against oxidative injury. However, the accompanying side effects are often detrimental and discouraging.
Vitamin C, with its ability to neutralize ROS, supports skin by helping to diminish the oxidative damage and resulting inflammation. When added to the everyday skin care it can improve health and appearance of acne skin or any type of skin with inflammation.

Read more about vitamin C:
www.nlm.nih.gov/medlineplus/vitamins,   www.nih.gov/news,   www.vitamincfoundation.org



A PERSONAL NOTE FROM DR. PIOTR CHOMCZYNSKI

Dear Customer: We are pleased to provide you with a patent-pending pill containing a Vitamin C - Calcium - Ginger Antioxidant Blend. This is our most recent entry in improvements of skin appearance in people affected by rosacea or acne.

There has been speculation that chemicals called free radicals, especially reactive oxygen species, play a role in triggering inflammatory skin conditions appearing in acne and rosacea. For this reason, certain cosmetics include vitamin C in their list of ingredients. However, topical delivery of vitamin C seems to be not highly effective. Our research indicates that oral use of Vitamin C - Calcium - Ginger blend combined with the topical use of Noredol® Skin Care Gel improves conditions of skin affected by rosacea and acne. Oral Vitamin C is an important antioxidant that counteracts reactive oxygen species damage in human tissues. Vitamin C may also improve appearance by promoting skin collagen synthesis.

The Vitamin C - Calcium – Ginger pills contain about 450 mg of vitamin C and should be taken two times a day. This is higher than the recommended daily allowance of 60 mg per day of vitamin C. But numerous studies using very high amounts of vitamin C, up to seven grams a day, showed no side effects with these very high doses. (These other studies examined vitamin C as a treatment for things like cancer, inflammation and the common cold.) To be safe, if you are pregnant or nursing, taking medication, have bleeding or other medical problems, consult a physician before taking this product.

In conjunction with taking this pill orally, apply Noredol® Skin Care Gel two-three times a day to your skin. Take one pill in the morning or in the evening, with or without food. Please take additional pill if you experience factors that trigger your skin condition to become worse, such as high intensity exercise, exposure to bright sun light, extreme temperatures or foods that trigger rosacea (for example coffee or tea). We recommend taking the pill before the exposure.

We expect that addition of the Vitamin C - Calcium - Ginger antioxidant blend into your daily routine, along with your continued use of Noredol® Skin Care Gel, will result in further improvement of your skin appearance.

A recent review indicates that many health claims associated with vitamin C are not confirmed in studies of large human populations. The one effect which seems to be confirmed is that vitamin C helps to handle physical stress. Similar to this finding, our study indicates that the vitamin C-Calcium-Ginger antioxidant blend can  improve the appearance of skin affected by stress due to environmental factors such as extreme weather or sun, and of skin stressed by conditions such as rosacea. In our studies, about 40% of people noticed skin improvement after taking the Vitamin C antioxidant blend. Take advantage of our free offer and judge for yourself.  For a limited period of time we provide a free bottle of this vitamin blend. Please send us an email with your comments and results.

Sincerely,
Piotr Chomczynski, PhD


"Red is beautiful but not on your face."


ROSACEA AND YOU                                                                                                                  ACNE AND YOU

    •    Skin barrier.                                                                                                       Keep it in good shape.

Rosacea or acne skin is extremely sensitive and hyper-reactive to many environmental, dietary as well as everyday skin care and skin hygiene products.  Resulting flare-ups aggravate skin condition and disrupt even more the natural skin barrier already compromised by rosacea or acne.  For that reason, keeping healthy skin barrier should be an important part of everyday care for the skin health and appearance.

Skin is a physical barrier to the environment.  Any alterations in the barrier properties or actual damage by external or internal factors affect barrier function and result in skin health problems.  A compromised skin barrier can facilitate bacterial infections, result in less effective skin repair, promote blotches, rashes, blemishes or skin disfigurations, just to mention a few.  Since a damaged skin barrier looses water rapidly, skin can become dry, flaky, cracked and inflamed.  This in turn is a first step towards infections aggravating its condition.

Rosacea is often recognized as a facial skin’s barrier condition, characterized by higher then normal water loss showing as visible skin dryness and extreme skin  irritability. In acne, the impaired water barrier together with blocked hair follicles and oil glands is blamed for comedo formation. Also excessive oil (sebum) secretion, skin inflammation, bacterial colonization, skin blemishes and skin breaks all impair the acne skin barrier function.

For all these reasons, protecting the skin’s barrier function in rosacea or acne should be a consideration for everyday skin care.

First, topical cosmetic products used everyday should not dry out the skin or bring any additional irritation that might aggravate the barrier condition of skin compromised by rosacea or acne. Noredol® Skin Care Gel can be a cosmetic of choice as it has a soothing, gentle formula that calms the skin without unwanted irritations and reduces appearance of redness, blemishes and flare-ups. Noredol® can be especially good choice for everyday care. It helps maintain healthy, beautiful skin without leaving visible residue and does not interfere with makeup or other cosmetic products. 

Second, products that support barrier integrity of rosacea or acne skin are products that help in the skin recovery.  The recovery is driven by growth of new skin cells that replace the old, damaged cells in the constant turn-over process.  The cell turn-over helps to repair skin damage and restore healthy, functional skin barrier.  Vitamin C and calcium have a profound role in the formation of a functional skin barrier.  As active agents in skin cell proliferation, skin differentiation and skin cell membrane formation, they regulate the skin cell turn-over and consequently the functional quality of the skin barrier.

Rosacea and acne skin needs special attention to keep the replacement of old damaged cells efficient, and the skin barrier repaired.  Adding supplemental vitamin C enriched with calcium in a pill as a daily addition to everyday skin care would be a reasonable choice for a person with rosacea or acne.  It keeps the skin barrier in good shape and is an important step to a healthier, beautiful complexion. 


    •    Your genes and acne.                                                        What to know about skin heritage.

Acne is one of the most common skin disorders, affecting most of the adolescent population, at the rate between 35% and 90%. 
The pathogenesis of acne is very complex and many aspects of acne skin wait to be understood.  One aspect of the condition that is just starting to be appreciated is the association between acne and genes.  Studies have shown that the severity of acne symptoms depends 81% on heredity, and only 19% on the environmental factors, like life style, diet, etc.  The influence of genetics on pathogenesis of acne has been particularly well documented in the case of twins: the identical twins were found more often to have the same acne symptoms, e.g. excessive oil (sebum) excretion, than non-identical twins. Acne skin also “goes” in families.  It has been shown in large genealogic studies that the frequency of acne was four times higher in descendants of the acne-affected than in descendants of the healthy members of the family tree.

At present, there are only a few reports concerned with finding an association between acne and particular gene or group of genes, and most of them address genes coding for proteins regulating seborrheic glands. The genes of interest also include those responsible for hormonal and bacterial aspects of acne symptoms.  These preliminary reports indicate that the characteristic symptoms of acne: the oily skin, testosterone imbalance and colonization of the pores and skin surface by P. propionicum can be tracked to particular gene(s) regulating sebum excretion by seborrheic glands/oil glands, testosterone production and ability of the cell membrane to prevent bacteria attachment to the cell surface.

How these highly scientific reports can be useful for us?  First, they create new options for medicinal approaches to acne problems.  On the other hand, for all of us they can be an invitation to look more closely at our genealogic connections to understand better our possible health prognosis.  Finding out the “acne-connection” in our hereditary tree should not be a reason for despair but rather an incentive to make a good plan for everyday preventive as well as cosmetic care for the skin even before any unwanted symptoms appear. 


Noredol® soothes and brings cool relieve.  Photo: Summer Breeze by Jan Barankiewicz

 NOREDOL® SKIN CARE GEL                                           COSMETIC OF CHOICE FOR YOUR NEEDS

        The combination approach:  supplement support for your skin.         At present, dermatologists often apply a combination approach to severe acne or rosacea, when inflammatory processes are already in full.  Their approach usually includes systemic (oral) anti-inflammatory antibiotics combined with topical application of skin products.  Both rosacea and acne are the skin conditions that require constant, everyday care to keep the symptoms under control and to help prevent or diminish the chance of them developing into the most severe stages. We believe that especially in the early stages of rosacea, when facial skin redness is a major symptom, a number and severity of flares can be kept to the minimum by diligent application of topical cosmetics with support of systemic  supplements.  We introduced a combination of vitamin C, ginger and calcium in one pill as a supplement to our topical cosmetic product, Noredol® Skin Care Gel.  Noredol® has prooven as a cosmetic of choice for facial redness, blemishes and flare-ups in the skin affected by rosacea or acne.  Its soothing and gentle action can be enhanced by our vitamin C supplement that delivers an everyday dose of the antioxidant and anti-inflammatory cover for rosacea or acne skin. Such a cover helps to keep the oxidative stress level that is markedly enhanced in these skin conditions under control and maintains a healthy and beautiful complexion.

        Noredol® after your laser IPL treatment.   “I was given a sample of Noredol after an IPL treatment and I have to say during a period of stress when I flare that if I apply it, it does have some soothing properties and in about a half hour my face does not hurt or feel flushed.” .”  That testimonial from a Noredol® user is a good news for those who plan to have a laser procedure such as IPL for their skin problems.  IPL, which stands for Intense Pulse Light, is a new, non-surgical (non-ablative) technique to treat several skin problems including persistent red complexion, broken capillaries and telangiectases, acne scars, large pores, sun spots and other skin blemishes. It is also used as a rejuvenation tool for the treatment of fine lines and wrinkles. An IPL procedure does not damage the surface of the skin as the intense light is delivered to the deeper parts of the skin (dermis) leaving the top layer of the skin (epidermis) untouched.  It is advertised as a technique that is safe: it requires virtually no recovery time, patients can even apply makeup before leaving the office and return to work the same day.  However, side effects are reported including transient redness and general skin irritation.  These can be alleviated by application of Noredol® Skin Care Gel. As  cosmetic that reduces it also provides the moisturizing that is needed and recommended after a laser procedure.   Thanks to its soothing, cooling, gentle formula, Noredol® is a cosmetic of choice for post laser IPL treated skin by helping to reduce the skin redness and irritation that are often side effects of the procedure.

Ginger Flower

MILLENNIA OLD OPINION:                                            EVERYTHING GOOD CAN BE FOUND IN GINGER.

Ginger has a long history as a spice for cooking and as an herbal remedy in the folk medicine of many cultures. The ancient Greeks ate ginger wrapped in bread to prevent nausea from the big feast. For millennia, Chinese sailors have taken ginger to avoid seasickness. The Bible (Solomon’s Song 4:14) lists calamus, a spice obtained from the plant closely related to ginger, among the most precious “chief spices”, together with “all trees of frankincense”, myrrh, aloes and cinnamon. A proverb from ancient India maintains that everything good can be found in ginger. Ginger today is an important spice in Asian and Western cooking, and has increasing reputation as a medicinal plant.

Ginger is a common name for a plant of Zingiberaceae family of tropical and subtropical perennials, that originated in South Asia. Many plants from the family contain aromatic oils that are used in making condiments, perfumes, and medicines. Ginger, turmeric and cardamom are the most important economic spices, produced in great quantities for international trade. Commercial ginger is made from the root of the ginger plant, Zingiber officinale, that is actually the underground fleshy stem called a rhizome. The root is either preserved by candying or dried and powdered for medicines and spices or sold fresh as a produce.

The name “ginger” comes from the Middle English gingivere that directly derived from the ancient Latin zinziberi. However the origins of the name “ginger” dates back over 3000 years to the Sanskrit word srngaveram, meaning “horn root”, that obviously alludes to the ginger root appearance.

Cultivated for millennia in China and India (the first reference can be found in the 3000 B.C. Chinese writings), ginger reached the West at least two thousand years ago. It was recorded as a subject of the Roman tax in the second century after being imported via the Red See to Alexandria. By the 13th century, it can be found in French tax records and is a part of English cooking recipes and prescriptions written by physicians, as evidenced in the 13th century work “Midday”. In the 14th century Europe, ginger was the most popular spice, next to pepper. In recent years ginger, both fresh and dried, has become increasingly popular in the United States. During the 1990s, on average, the US imported more than 4,000 metric tons of ginger per year.

Valued for the distinctive tang it lends to cuisine, ginger root has been used for millennia as a medicinal remedy. Chinese medical texts from the fourth century B.C. prescribe ginger for treating nausea, diarrhea, stomachaches, cholera, toothaches, bleeding, and rheumatism. Ginger is still present in the contemporary Chinese medicine as a remedy for a number of health complaints. As an approved drug recommended for indigestion and motion sickness, ginger is listed in the official German pharmacopoeia.

In modern times, ginger has been extensively studied for a broad range of medicinal properties. At present, there is a quite good collection of data indicating that ginger, by relaxing peripheral blood vessels, works as a circulatory regulator. It is also described as a factor preventing formation of new blood vessels. In agreement with the long tradition, ginger is confirmed as an anti-inflammatory and anti-bacterial remedy, and interestingly, it kills Helicobacter pylori, bacteria often recognized as one of the roots for the development of rosacea condition. All this contemporary medicinal data fits quite nicely into the millennia old opinion handed down to us by wise men of India that says: everything good can be found in ginger.

Topics you would like addressed?
Email: editor@noredol.info

Copyright © 2006 - 2008
Molecular Research Center, Inc.
Noredol® is a registered trademark
of Molecular Research Center, Inc.

bottom logo